Association of Helicobacter Pylori Infection and Radical Treatment with IgA Nephropathy:A Meta-analysis
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维普
万方数据
目的 通过Meta分析探索IgA肾病患者幽门螺杆菌(Hp)感染率以及根治Hp后对IgA肾病的影响.方法 计算机检索中国知网、万方数据知识服务平台、维普网、中国生物医学文献数据库(CBM)、PubMed、Embase、Cochrane Library、Web of Science,收集建库至 2023 年 7 月 30 日发表的有关 IgA 肾病合并Hp感染和根治的回顾性队列研究.结果 总共纳入18篇文献共1 615例IgA肾病患者,Egger's回归显示无发表性偏倚,敏感性分析显示结果稳健,Meta分析结果显示,IgA肾病患者Hp感染率高于健康对照者(OR=1.51,95％CI 1.13-2.02,P＜0.05);IgA肾病患者中Hp根治组与未抗Hp常规治疗对照组临床指标比较:估算肾小球滤过率(eGFR)、血清肌酐(Scr)、血尿素氮(BUN)、24 h尿蛋白定量(24 h-UTP)、白蛋白(ALB)、总胆固醇(TC)变化差异均无统计学意义(P＞0.05).结论 IgA肾病患者Hp感染率明显高于健康对照者,提示IgA肾病与Hp感染可能存在关联性;IgA肾病患者中Hp根治组与未抗Hp常规治疗对照组治疗前后临床指标无明显变化,有待进一步扩大样本量、延长随访时间观察结局指标差异.
Objective To explore the infection rate of Hp in patients with IgA nephropathy and the effect of radical Hp treatment on IgA nephropathy through meta-analysis.Methods Computer search China National Knowledge Network,Wanfang Database knowledge service platform,VIP network,China Biomedical Litera-ture Database(CBM),PubMed,Embase,Cochrane Library,Web of Science,Retrospective cohort studies on IgA nephropathy with helicobacter pylori infection and radical treatment published until 2023-07-30 were col-lected.Results A total of 18 literatures were included,involving 1615 patients with IgA nephropathy.Egger's regression showed no publication bias,sensitivity analysis showed robust results,and Meta analysis showed:The infection rate of Hp in IgA nephropathy patients was higher than that in healthy controls(OR=1.51,95％CI 1.13-2.02,P＜0.05).There were no significant differences in eGFR,Scr,BUN,24 h urinary protein,al-bumin and total cholesterol in IgA nephropathy patients between the Hp radical treatment group and the control group without anti-HP conventional treatment(P＞0.05).Conclusion The infection rate of Hp in IgA nephropathy patients was significantly higher than that in healthy controls without nephropathy,suggesting that there may be a correlation between IgA nephropathy and Hp.There was no significant change in the clinical in-dexes of IgA nephropathy patients in the Hp radical treatment group and the control group without anti-HP conventional treatment before and after treatment.It is necessary to further expand the sample size and extend the follow-up period to observe the difference in outcome indexes.
维普
万方数据
