Objective This paper aims to analysis of the correlation between the Adverse pregnancy history and fetal chromosome abnormalities.Methods The karyotype analyses were carried out on 209 pregnant women with prenatal diagnosis indications in Inner Mongolian Maternal and Child Health Hospital from January 2021 to December 2022;Observe the incidence,distribution,and statistical features of adverse pregnancy and childbirth history combined with chromosome abnormality of one parent and at an advanced age.Results The abnormal detection rate of chromosome karyotype analysis was 0.96％in pregnant women with adverse pregnancy history alone,and all the detected results were chromosomal structural abnormalities.The incidence of abnormal kary-otype in multiple indicator group was significantly higher than that in single indicator group,and the difference in detection rate was statistically significant(P＜0.01).The detection rate of chromosome karyotype abnormali-ties in couples with adverse pregnancy history was 3.83％(8/209),accounting for 26.67％(8/30)of the total chromosome karyotype abnormalities.The karyotypes detected were all structural abnormalities.When a history of adverse pregnancy is combined with chromosomal abnormalities in one spouse,the probability of the surviving offspring chromosome is 1/2 the same as the chromosome karyotype of the abnormal parent or mother.The de-tection rate of abnormal chromosome karyotype results of adverse pregnancy combined with old age was 5.74％(12/209),accounting for 40.00％(12/30)of the total chromosome karyotype abnormalities.The number of abnormal chromosome karyotype abnormalities was mainly detected(8/12),and the proportion of trisomy 21 was the highest(5/8).These results indicate that trisomy 21 syndrome is still the main type of fetal chromoso-mal abnormality in old pregnant women with adverse pregnancy.Conclusion Prenatal karyotype analysis of pregnant women with adverse pregnancy history can effectively prevent the birth of defective.
维普
万方数据
