Objective To analyze the clinical characteristics of preterm infants hospitalized in Neonatal In-tensive Care Unit(NIUC)of our hospital in recent 3 years,and to grasp the clinical characteristics of hospital-ized premature infants.Methods A total of 523 premature infants hospitalized in the NICU of Inner Mongolia Autonomous Region People's Hospital between January 2020 and June 2023 were selected as the research sub-jects,and they were divided into extremely preterm infants(gestational age<28 weeks)、very preterm infants(gestational age 28~31+6 weeks)and middle-late preterm infants(gestational age 32~36+6 weeks)according to gestational age,then the retrospective analysis method was used to compare the clinical data and the occur-rence of complications during hospitalization of the three groups of preterm infants.Results(1)Among the 523 premature infants admitted,the gestational age was mainly 32~36+6 weeks(73.6%,385/523);(2)The first three disorders with a higher incidence in preterm infants in this data were:neonatal jaundice(91.0%,476/523),preterm brain injury(50.5%,264/523)and NRDS(28.7%,150/523);(3)Thegestational age<28 weeks group had more common diseases such as NRDS(100.0%,30/30)、neonatal jaundice(90.0%,27/30)and preterm brain injury(90.0%,27/30),the top three diseases in 28~31+6 weeks group were neonatal jaundice(88.9%,96/108)、preterm brain injury(71.3%,77/108)、NRDS(68.5%,74/108),the top three diseases with the highest incidence at 32~36+6 weeks were:neonatal jaundice(91.7%,353/285)、preterm brain injury(41.6%,160/385)and temporary thyroid dysfunction(25.2%,97/385);(4)The diseases with the highest in-cidence in the nervous、respiratory、circulatory、digestive and hematologic system were:preterm brain injury(50.5%,x2=49.723,P<0.001)、NRDS(28.7%,x2=211.093,P<0.001)、PDA(25.2%,x2=84.812,P<0.001)、feeding intolerance(14.9%,x2=33.804,P<0.001)、anemia(24.3%,x2=54.074,P<0.001),the incidence of each disease among the three groups decreased with the increase of gestational age,and the differences were statistically significant;(5)Among the 523 hospitalized live births of preterm infants,2 cases(0.4%)were died,19 cases(3.6%)were voluntarily discharged or gave up,and 502 cases(96.0%)were cured or discharged,and the treatment rate was closed to the national average.Conclusions The incidence of diseases in different gestational age groups was different,and the incidence of premature infants in different gestational age groups of the same disease was also different,the smaller the gestational age,the higher the inci-dence;targeted prevention,timely diagnosis and treatment of diseases is the key to reduce the morbidity and mortality in preterm infants to improve their cure rate.