Objective To investigate the relationship between changes in maternal lipid levels during preg-nancy and congenital heart disease(CHD)in the offspring,and to provide a basis for the prevention and treat-ment of CHD in children.Methods A total of 77 pregnant women who underwent obstetric examination and delivered in Inner Mongolia Autonomous Region Maternal and Child Healthcare Hospital from May 2021 to May 2022 were selected,of which 34 cases in the case group were pregnant mothers with fetal CHD,and 43 cases in the normal control group were pregnant mothers with healthy fetuses.Blood biochemical indexes of pregnant mothers in both groups were measured,including total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),and low-density lipopro-tein cholesterol(LDL-C).density lipoprotein cholesterol(HDL-C),apolipoprotein-A1(Apo-A1),apolipoprotein-B(Apo-B),and fasting plasma glucose(FPG).Binary logistic regression was used to analyze the correlation between maternal lipid levels and CHD in offspring.Results Compared with the control group,the levels of HDL-C and Apo-A1 in mothers of CHD children were significantly decreased,and Apo-B/A1 was increased,with statistical significance(P＜0.05).After adjusting for potential confounding factors,HDL-C(OR=0.180,95％CI=0.034-0.947,P=0.043)and Apo-A1(OR=0.957,95％CI=0.934-0.981,P=0.001)levels were negatively correlated with the occurrence of CHD.Apo-B/A1(OR=1.033,95％CI=1.004-1.062,P=0.024)was positively correlated with CHD.Conclusion Low levels of HDL-C and Apo-A1 during pregnancy increase the risk of CHD in offspring,and abnormal levels of lipid metabolism are associated with congenital heart disease in offspring.Maintaining appropriate blood lipid levels before and during pregnancy is of great significance for the prevention of CHD and other child birth defects.
congenital heart diseasepregnancyblood lipidHigh density lipoprotein cholesterol
维普
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