Objective The purpose of this study was to investigate the relationship between levels of uric acid(UA),homocysteine(HCY),and stage and cognitive function changes in Parkinson's disease(PD).Through this study,we seek a new path for the diagnosis of early PD and early cognitive impairments,thereby giving ear-ly intervention and reducing complications.Methods A total of 60 PD patients and 60 healthy checkers admit-ted to our hospital from 2015 to 2018 were selected as the study subjects.And measure their serum uric acid,cre-atinine,and homocysteine concentrations.Using Hoehn-Yahr(H-Y)staging,patients in the PD group were divided into two subgroups:The early(1-2.5)and mid-late(3-5)groups.Using the Montreal cognitive as-sessment(MoCA),PD was divided into two subgroups:cognitive dysfunction and normal cognitive function.We compared the levels of serum UA and HCY between patients with Parkinson's disease and normal controls and between PD subgroups.Results(1)Serum UA levels in the PD group were significantly lower than those in the control group.(2)The serum HCY level in the PD group was significantly higher than that in the control group.(3)Serum UA in the mid-late PD group was lower than that in the early group.HCY levels in the mid-late PD group were significantly higher than those in the early PD group.(4)Serum UA in PD cognitive impairment group was lower than that in normal cognitive function group.(5)HCY levels in PD cognitive dysfunction group were higher than PD cognitive function normal group.Conclusion Serum uric acid and homocysteine may play an important role in the detection of early PD and its early cognitive dysfunction.Increasing blood UA and reducing HCY may be the strategies to control or delay the rapid progression of PD and improve cognitive function.
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