Objective To explore the possible mechanism of Fufanglongxuejie Capsules in treating angina pectoris by network pharmacology.Methods The related chemical components of three Chinese medicines in Fufanglongxuejie Capsules were collected by TCMSP database,BATMAN-TCM database,and related litera-tures by Pub Med and CNKI.DrugBank,SwissTargetPrediction were used to obtain the targets of Fufang-longxuejie Capsules.GeneCards,OMIM and TTD databases were used to search the potential targets of"angina pectoris",and then the core targets of Fufanglongxuejie Capsules and angina pectoris targets were obtained.A protein-protein interaction(PPI)network and the"Fufanglongxuejie Capsules composition-components-tar-gets"network were constructed by STRING database and Cytoscape 3.7.2 software.GO analysis and KEGG pathway analysis were performed by using R software.Results Fufanglongxuejie Capsules contained 107 active components,568 targets,and 50 potential targets with angina pectoris were obtained.GO analysis and KEGG analysis showed that they involved 1033 biological processes,62 molecular functions,39 cellular components,and 13 signaling pathways.Conclusion Fufanglongxuejie Capsules can treat angina pectoris through multi-components,multi-targets and multi-pathways interaction,which provides a new direction for the basic and clinical research of Fufanglongxuejie Capsules in the treatment of angina pectoris.
维普
万方数据