Objective To explore the risk factors for high-grade Squamous intraepithelial lesion or worse lesions(HSIL+)in patients with HPV16/18 positive and Thinprep cytologic test(TCT)normal,and to con-struct a risk prediction model.To provide clinicians with an adjunctive assessment tool for referral colposcopy and cervical biopsy.Methods A total of 207 patients who were positive for HPV16/18 and normal TCT and col-poscopy+cervical biopsy pathology were collected from June 2021 to June 2023,and the independent risk fac-tors were screened by logistic regression analysis,the prediction model was constructed,the connection graph was established,and the predictive performance,compliance,accuracy and clinical practicability of the model were evaluated.Results(1)One-way chi-square test showed BMI(x2=12.13,P＜0.001),Smoking(X2=15.28,P＜0.001),vaginal microecology(x2=10.074,P=0.002),Time of infection(x2=82.444,P＜0.001),Vaginal state(x2=66.458,P＜0.001)was an independent risk factor for HSIL+in patients with positive HPV16/18 and normal TCT;(2)The AUC of the risk prediction model was 0.94(95％CI=0.89-0.98);(3)the consistency index(C-index)of the nomogram model was 0.937 after internal verification.Con-clusion The prediction model established based on BMI,vaginal microecology,smoking,infection time and vaginal status in this study predicts the occurrence of HSIL+in patients with positive HPV16/18 and normal TCT,which has good discrimination,accuracy and clinical practicability,which can provide a reference for clin-icians facing HPV16/18 positive and normal TCT patients with colposcopy+cervical biopsy.
HPV16/18high-grade intraepithelial lesions of the cervixTCT
维普
万方数据
