Objective To investigate the relationship between the abnormal changes of blood glucose levels and hypertensive disorders of pregnancy(HDP)and pregnancy outcomes in patients with gestational diabetes mellitus(GDM).Methods The different levels of blood glucose of 75 g oral glucose tolerance test(OGTT)were examined to study the maternal characteristics;the adverse pregnancy and neonatal outcomes by number of elevated glucose values;the relationship between FPG levels,post-load blood glucose levels or drug interven-tion and the large-for-gestational age(LGA)infants or HDP.Results There were 305 GDM pregnancies,of which 159(52.13％)had an elevated FPG,and 146(47.87％)had post-load(1-h and/or 2-h)glucose el-evation.LGA and HDP rates Were 24.50％and 14.50％in GDM pregnancies with elevated FPG levels,and 9.60％and 6.20％in GDM pregnancies with elevated post-load glucose levels,respectively.GDM pregnancies needed drug treatment for the three levels including elevated fasting plasma glucose(FPG)than for the other lev-els,and the differences were statistically significant(P＜0.05).Among GDM pregnancies,elevated FPG was associated with a signi cantly higher risk of having LGA infants and of HDP outcomes compared with elevated post-load glucose(P＜0.01).Pharmacological treatment was associated with higher risk of LGA infants out-comes(P＜0.05).Conclusion Elevated FPG is a stronger predictor of LGA infants and HDP outcomes than post-load glucose elevation in GDM pregnancies.
gestational diabetes mellitusglucose tolerance testfasting plasma glucoselarge-for-gesta-tional age infants
维普
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