Objective To screen the key genes of ischaemic stroke(IS)combined with hyperuricemia(HUA)by raw letter analysis and to predict Chinese medicine.Methods Microarray data of HUA and IS were downloaded from the Gene Expression Omnibus(GEO)database.R packages were identified for co-expressed expressed genes associated with HUA and IS.The shared genes present in HUA and IS were enriched and anal-ysed for biological processes using DAVID,and their key genes were screened and validated using cytocape.Fi-nally,eight key genes were used for mapping to screen the Chinese medicines turmeric,danshen and scutellaria.Results Fifty-one genes were identified and enriched as shared genes of HUA and IS,and inflammatory re-sponse was found to be a common feature of HUA and IS pathophysiology.And based on the shared and key gene features in HUA and IS,their corresponding potential herbal medicines were mapped.Conclusion Biosense was used for key gene exploration of HUA combined with IS and to identify novel candidate genes that can be used as biomarkers or potential therapeutic targets and herbal medicine predictive analyses.
GEOhyperuricaemiaischaemic stroketraditional Chinese medicine
维普
万方数据
