Objective To detect the expression of fibronectin and Vascular Endothelial Growth Factor in myocardium of coronary heart disease.Methods Autopsy samples of coronary paraffin section observed by the light miscroscope and divided into two groups:the normal coronary and the atherosclerotic plaque group.The immunohistochemical method and computerized imaging analysis were used to detect the expression of Fn and VEGF in myocardium according to the two groups of coronary respectively.Results In expression of Fn and VEGF of myocardial,a significant difference was found among the normal coronary and the atherosclerotic plaque group(P＜0.01).Conclusion The result indicates that Fn and VEGF may be used as the parameters for diagnosis of human myocardial ischemia.
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