Objective:To analyze the clinical distribution characteristics and the change and trend of coagu-lase-negative Staphylococcus(CNS)and methicillin-coagulase-resistant Staphylococcus(MRCNS)of an-timicrobial resistance in Ordos Central Hospital from 2018 to 2022,and to provide a basis for the rational use of antibiotics in clinical practice.Methods A retrospective analysis of CNS and MRCNS specimens,distribution of clinical infection departments and resistance changes from January 2018 to December 2022.Results A total of 14027 strains were isolated from clinical specimens from January 2018 to December 2022,Among which,the CNS 877 strain,Of the population was 6.25％,The main subtypes of CNS strains were Staphylococcus epider-midis(55.53％),Staphylococcus hominis(16.65％),Staphylococcus haemolyticus(14.37％),etc.CNS mainly isolated spontaneous secretions(23.72％),blood(21.21％),drainage fluid(17.79％),urine(17.10％),etc.The highest detection rate in neurosurgery(16.88％),Followed by orthopedics(14.71％),pediatrics(13.68％);CNS showed the highest resistance to penicillin G,Over 87.00％in all five years,Main-taining high resistance rates to antibiotics such as erythromycin,oxacillin,cefoxitin,and levofloxacin,Between 51％and 80％,Low resistance rates to antibiotics such as clindamycin,moxifloxacin,gentamicin,and ri-fampicin,Between 7％and 45％,No strains of vancomycin resistant to vancomycin,linezolid,tigecycline,and teicoplanin were found in five years;The MRCNS 599 strain was detected in the CNS,Accounted for 68.30％,The detection rate of MRCNS strains decreased from 2018 to 2020,But in 2020,a marked turn in the detection rate,Increasing detection rate from 2020-2022,No MRCNS isolates showed vancomycin,linezolid,tigecy-cline,and teicoplanin resistance,There was a trend towards decreasing resistance rates to erythromycin,cotri-moxazole,clindamycin,rifampin,and other antibiotics,The resistance rate to levofloxacin,moxifloxacin and gentamicin was increasing.Conclusion Through the coagulase negative Staphylococcus infection in clinical de-partments distribution and resistance changes,coagulase negative Staphylococcus for a variety of antimicrobial resistance is serious,especially MRCNS drug resistance is more serious,should cause clinical department,to be more reasonable,standardized application of antibiotics,avoid the production of drug-resistant strains,and provide scientific reference for clinical infection prevention and control.
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