Objective:This article aims to investigate the diagnostic significance of serum soluble growth stimulating gene 2 protein(sST2)and monocyte/lymphocyte ratio(MLR)levels for patients with unstable angina complicated with hyperuricemia and their correlation with disease severity.Methods A total of 197 pa-tients diagnosed with UA combined with HUA who received chest pain at Inner Mongolia Autonomous Region People's Hospital from December 2022 to September 2023 were selected as the study subjects.Based on the imaging results,the patients were divided into mild group(Gensini≤30 points,n=93)and moderate to severe group(Gensini≥30 points,n=104)according to the Gensini score.According to the number of coronary artery lesions,they are divided into single vessel lesions(n.=77),double vessel lesions group(n=57),and multi ves-sel lesions group(n=63).All groups were tested for sST2 and MLR,and the correlation between serum sST2 and MLR analysis and the severity of coronary artery disease(number of coronary artery disease branches and Gensini score),as well as the predictive value of the combination of sST2 and MLR on the severity of coronary artery disease in patients with UA combined with HUA.Results(1)Theage,BMI,smoking,drinking,hy-pertension,diabetes,TC,LDL,monocytes,HCY in the moderate and severe stenosis group were significantly higher than those in the mild stenosis group(P＜0.05);There was no statistically significant difference between the two groups in terms of gender,TG,HDL,lipoprotein a,lymphocytes,and uric acid levels(P＞0.05).(2)The levels of sST2 and MLR in the moderate to severe stenosis group were significantly higher than those in the mild stenosis group,with statistical significance(P＜0.05).(3)The serum levels of sST2 and MLR in patients with multi vessel stenosis were higher than those in patients with single vessel stenosis,and the difference was statistically significant(P＜0.05);The serum levels of sST2 and MLR in patients with multi vessel stenosis were significantly higher than those in patients with double vessel stenosis(P＜0.05).(4)In multivariate logis-tic regression analysis,the results showed that:age(OR=1.09,95％CI 1.05-1.14),BMI(OR=1.18,95％CI 1.08-1.29),smoking(OR=2.41,95％CI 1.18-4.90),alcohol consumption(OR=2.97,95％CI 1.18-7.49),diabetes(OR=2.32,95％CI 1.03-5.23)TC(OR=1.91,95％CI 1.36-2.68)is a risk fac-tor for developing coronary artery stenosis in patients.(5)The risk of moderate and severe coronary artery steno-sis increased with the increase of the level of sST2(OR=2.18,95％CI 1.50-3.15,P＜0.001).After adjust-ing for age,gender,BMI,smoking,drinking,diabetes,TC and other factors,the increase of the level of sST2 was still the risk factor of moderate and severe coronary artery stenosis.The risk of moderate to severe coronary stenosis increased with the increase of MLR(OR=1.98,95％CI 1.38-2.85,P＜0.001)level.After adjusting for age,gender,BMI,smoking,drinking,diabetes,TC and other factors,the increase of MLR level was still a risk factor for moderate to severe coronary stenosis.(6)Draw ROC curves to evaluate the predictive value of sST2 and MLR for moderate to severe coronary stenosis.The area under the ROC curve of sST2 is 0.68,with an area under the curve greater than 0.5,and the difference is statistically significant(P＜0.05).Further cal-culation shows that the Jordan index of sST2 is 0.34,and the corresponding optimal cutoff value for sST2 is 25.83 ng/mL(sensitivity 58.65％,specificity 75.27％).This suggests that when sST2 is greater than 25.83 ng/mL,it has certain diagnostic significance for severe coronary stenosis.The area under the ROC curve of MLR is 0.66,with an area under the curve＞0.5,indicating a statistically significant difference(P＜0.05).The Jordan index of MLR is 0.30,and its optimal cutoff value is 0.31(sensitivity 53.85％,specificity 76.34％),indicating that.Conclusion The levels of sST2 and MLR in the blood of patients with unstable angina and hyperuricemia are elevated,and their levels are related to the severity of coronary artery disease.
维普
万方数据
