Objective:To analyze retrospectively the risk factors of endovascular therapy affecting prognosis of a-cute ischemic stroke.Methods A total of 70 patients with acute ischemic stroke diagnosed with acute anterior circulation large vessel occlusion from June 2018 to December 2022 were selected.All patients received Endovascular thrombectomy(EVT)within 24h,and improved Rankin score(mRS)was used to evaluate the recovery of nerve function at 90 days after EVT.According to mRS Scores,the patients were divided into good prognosis group(mRS≤2 points)and poor prognosis group(mRS≥3 points).The difference between the two groups was compared,and the data between the two groups were analyzed by binary Logistic regression to obtain the risk correlation,and the working curve(ROC)was made to guide and evaluate the prognosis of patients after EVT.Results There were significant differences in baseline blood glucose,baseline NIHSS score,OTP,PTR and postoperative sICH transformation between the two groups(P<0.05).Bi-nary Logistic regression analysis results showed:Blood glucose level(OR=1.657,95%CI 1.101-2.495,P<0.05),time from onset to puncture(OR=1.008,95%CI 1.000-1.016,P<0.05),time from puncture to recalculation(OR=1.054,95%CI 1.010-1.099,P<0.05)and symptomatic intracranial hemorrhage(OR=142.469,95%CI 7.161-2834.522,P<0.05)were independent risk factors for poor prognosis.Conclusions Preoperative elevated blood glucose,prolonged OTP and PTR,and postoperative sICH were independent risk factors for EVT prognosis in AIS patients.