To Investigate the Changes of Serum Asprosin Levels in Diabetic Retinopathy Patients at Different Stages
Objective To determine the serum levels of adipose factors such as Asprosin,Superoxide Dis-mutase(SOD),malondialdehyde(MDA)and vascular endothelial growth factor(VEGF)in patients with dia-betes retinopathy(DR),and to analyze the correlation between the four factors and DR and oxidative stress.Methods 139 patients with Type 2 diabetes Mellitus(T2DM)hospitalized in the ophthalmology department of the People's Hospital of Inner Mongolia Autonomous Region from November 2022 to October 2023 were select-ed for the study;The patients were divided into three groups according to DR staging criteria:proliferative dia-betes retinopathy(PDR)group(39 cases),non proliferative diabetes retinopathy(NPDR)group(47 cases),diabetes non diabetic retinopathy(NDR)group(53 cases),and simple cataract patients(61 cases)as the con-trol group.The serum levels of Asprosin,SOD,MDA and VEGF were measured by enzyme-linked im-munosorbent assay.At the same time,the patient's gender,age,weight,height,BMI,course of diabetes,fasting plasma glucose(FPG),fasting C-peptide,glycosylated hemoglobin(HbA1c),fasting insulin(FIN),low-density lipoprotein cholesterol(LDL-C),triglyceride(TG),and total Total cholesterol(TC),high den-sity lipoprotein cholesterol(HDL-C)and other indicators,calculate the Homeostatic model assessment of in-sulin resistance(HOMA-IR),and statistically analyze the above data.Results The serum levels of Asposin,MDA,and VEGF in PDR patients were higher than those in NPDR group and NDR group,all higher than those in NC group.The difference between the two groups was statistically significant;Correlation analysis showed that the course of diabetes HbA1c、FIN、FPG、HOMA-IR、Fasting C-peptide,HDL-C,LDL-C,HS-CRP are correlated with Asposin.MDA and the course of diabetes HbA1c、FIN、FPG、HOMA-IR、There is a correlation between fasting C-peptide and LDL-C;VEGF is correlated with HbA1c,FIN,FPG,HOMA-IR,HDL-C,LDL-C,and HS-CRP;SOD was associated with the course of diabetes,HbA1c,FPG,FIN,HOMA-IR,HDL-C,LDL-C and HS-CRP.Four factors are correlated with DR.Asposin predicts that the area under the ROC curve of DR is 0.903,the area under the SOD curve is 0.923,the area under the MDA curve is 0.902,and the area under the VEGF curve is 0.899.Conclusion Asposin,SOD,MDA,and VEGF are all correlated with DR;The levels of Asposin,MDA,and VEGF in serum increase with the severity of DR;Asposin,SOD,MDA,and VEGF have a certain predictive effect on DR,among which Asposin is better than MDA and VEGF.When its Jordan index is highest,its specificity and sensitivity are 73.68％and 90.70％,respectively.Asposin may be used as a new type of adipose factor to predict the occurrence of DR.
万方数据
维普
