In order to achieve lightweight of the car door,the stiffness and modal of the car door are first ana-lyzed to ensure that all performance requirements are met.The sensitivity analysis results of mass and modal fre-quency are used to screen out the plate thickness of some components of the car door as design variables.The op-timal Latin hypercube experimental design method is combined with finite element simulation model to solve the basic data collection for constructing a second-order response surface model,On the basis of the second-order re-sponse surface model,multi-objective optimization is carried out by combining the second generation non domina-ted genetic algorithm.The results show that the quality of the car doors has decreased by 4.45%.