Association between fasting insulin levels and recurrent metastasis in tumor patients
Objective:To explore the association between fasting insulin level and tumor recurrence and metastasis.Methods:153 tumor patients without diabetes in Suzhou Hospital of Traditional Chinese Medicine were collected from May to October 2021 by a cross-sectionsal study.137 non-diabetic cancer patients including pancreatic,hepatocellular,breast and lung can-cer in the First Hospital of Soochow University,Kunshan Hospital of Traditional Chinese Medicine and Yancheng Second People's Hospital were collected from January to December 2022 by a cross-sectional study.Unpaired t test or Mann-Whit-ney nonparametric test was used for measurement data,and χ2 or Fisher's exact test was used for count data,and Spearman's correlation analysis was used for correlation.Results:125(81.7%)of 153 tumor patients presents normal range fasting insulin levels,and the tumor recurrence and metastasis rate was the lowest in the grade of>5.0-10.0 μU/mL.Compared with the grade of>5.0-10.0 μU/mL,an increase or decrease in fasting insulin level grade,the recurrence and metastasis rate gradually increased(P<0.05),and there was a positive weak correlation(r=0.290,P=0.004)and a negative weak correlation(r=-0.189,P=0.061)between them,respectively.While there was no significant difference in non-operative tumor patients(P>0.05),the rate of recurrent metastasis was increased by either increasing or decreasing fasting insulin level grade in postoperative tumor pa-tients(P<0.05).The fasting insulin level in patients with recurrent metastasis of liver cancer was at a high grade level,and the mean value was significantly higher than that in the non-recurrent metastasis group(P<0.05).The fasting insulin level in patients with pancreatic cancer was at a low grade level,and the mean value in the recurrent metastasis group was lower than that in the non-recurrent metastasis group(P<0.05).The fasting insulin level in patients with recurrent metastasis of breast cancer showed a dichotomous distribution trend,and the mean value was higher than that in the non-recurrent metastasis group(P<0.05).The fasting insulin level in recurrent metastases of lung cancer was no significant difference that in non-recurrent metastases group(P>0.05).Conclusion:The increase or decrease of fasting insulin level within the clinical normal range may be one of the risk factors for recurrent metastasis in tumor patients,especially for the risk prediction and therapeutic targeting of postopera-tive recurrent metastasis in liver cancer,pancreatic cancer and breast cancer.
fasting insulintumor recurrence and metastasiscorrelationliver cancerpancreatic cancerbreast cancer
NETL
NSTL
万方数据
维普
