双相抑郁患者快感缺失与童年创伤经历的相关性
Childhood trauma is correlated to anhedonia in patients with bipolar depression
张沛云 1张瑶 2王潇潇 2刘超 1秦倩倩 1王培涓 1吕钦谕 2易正辉2
作者信息
- 1. 南通市第四人民医院普通精神科,江苏 226007
- 2. 上海交通大学医学院附属精神卫生中心临床六科;复旦大学附属华山医院精神科
- 折叠
摘要
目的:探讨双相抑郁患者快感缺失与童年创伤经历的关联性.方法:采用斯奈思-汉密尔顿快感量表(Snaith-Hamilton pleasure scale,SHAPS)、中文版修订社会快感缺失量(revised social anhedonia scale-Chinese version,RSAS-C)、中文版修订躯体快感缺失量表(revised physical anhedonia scale-Chinese version,RPAS-C)、17项汉密尔顿抑郁量表(17-item Hamilton rating scale for depression,HAMD-17)、14项汉密尔顿焦虑量表(14-item Hamilton anxiety scale,HAMA-14)和童年创伤问卷(childhood trauma questionnaire,CTQ)对53例双相抑郁患者(观察组)和51名健康者(健康对照组)进行评估,通过偏相关分析探讨双相抑郁患者快感缺失与童年创伤的关系.结果:观察组SHAPS、RSAS-C、RPAS-C、CTQ的总分及其分量表情绪虐待、躯体虐待、情绪忽视和躯体忽视评分均高于健康对照组(P＜0.05).RPAS-C评分与CTQ总分及性虐待、躯体虐待评分呈正相关(P＜0.05).结论:童年创伤经历与双相抑郁患者快感缺失相关联,特别是早年的创伤经历影响个体对躯体快乐的体验能力.
Abstract
Objective:To explore the relationship between anhedonia and childhood trauma in patients with bipolar depression.Methods:The Snaith-Hamilton pleasure scale(SHAPS),revised social anhedonia scale-Chinese version(RSAS-C),revised physical anhedonia scale-Chinese version(RPAS-C),17-item Hamilton rating scale for depression(HAMD-17),14-item Hamilton anxiety scale(HAMA-14)and childhood trauma questionnaire(CTQ)were used to evaluate 53 patients with bipolar depression(observation group)and 51 healthy persons(healthy control group),the relationship between anhedonia and childhood trauma was analyzed by partial correlation in patients with bipolar depression.Results:The total scores of SHAPS,RSAS-C,RPAS-C,CTQ and its subscales included emotional abuse,physical abuse,emotional neglect and physical neglect scores in the observation group were higher than those in the healthy control group(P＜0.05).A positive correlation was found between the RPAS-C score and the total score of CTQ,sexual abuse,physical abuse scores(P＜0.05).Conclusion:Childhood trauma is correlated to anhedonia in patients with bipolar depression,particularly early trauma experiences that affect an individual's ability to experience physical pleasure.
关键词
双相抑郁/快感缺失/童年创伤Key words
bipolar depression/anhedonia/childhood trauma引用本文复制引用
基金项目
科技部科技创新2030"脑科学与类脑研究"重大项目(2022ZD0208500)
南通市科技局项目(MS22022098)
南通市卫生健康委项目(QN2023041)
江苏省科技计划重点研发计划(BE2020661)
南通市卫生健康委项目(QN2022047)
出版年
2024
NETL
NSTL
万方数据