Predictive value of red blood cell distribution width to albumin ratio combined with INR in cirrhosis complicated by hepatic encephalopathy
Objective:To investigate the predictive value of the red blood cell distribution width/albumin ratio(RAR)combined with the international normalized ratio(INR)on the prognosis of cirrhosis complicated by hepatic encephalopathy(HE).Meth-ods:The clinical data of 160 patients with cirrhosis complicated by hepatic encephalopathy treated at the Nantong Third Peo-ple's Hospital from June 2018 to June 2022 were retrospectively collected and analyzed.Based on the 90-day prognosis,the patients were divided into 109 cases in the survival group and 51 cases in the death group,and the clinical data,laboratory tests and other indicators of the two groups were compared.Cox regression was applied to analyze the relevant factors affecting the prognosis of hepatic encephalopathy,and ROC curves were drawn to assess the predictive efficacy of RAR combined with INR on cirrhosis complicated by hepatic encephalopathy.Results:Total bilirubin,albumin,serum sodium,INR,erythrocyte fractionation width,platelet count,RAR,model for end-stage liver disease(MELD)score,Child-Turcotte-Pugh(CTP)score,and MELD-Na score were statistically significant(all P＜0.05)when comparing patients in the surviving group with those in the death group.Multifactorial Cox regression analysis of the above variables showed that RAR(OR=1.105,95％CI:1.051-1.161,P＜0.001)and INR(OR=0.259,95％CI:0.069-0.965,P=0.044)were independent risk factors affecting the short-term prognosis of patients with cirrhosis complicated by hepatic encephalopathy.The results of ROC curve analysis showed that the AUC for the three scoring models of RAR,INR,and RAR combined with INR were 0.803,0.712,and 0.812,respectively.Conclusion:RAR combined with INR has high predictive efficacy in patients with cirrhosis complicated by hepatic encephalopathy,and can be used as a biological indicator to predict cirrhosis complicated by hepatic encephalopathy.
liver cirrhosishepatic encephalopathyred blood cell distribution width/albumin ratiointernational normalized ratioprognosis
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NSTL
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