Clinical analysis of the risk factors for recurrence of perianal and anal condyloma acuminatum patients treated by fractional carbon dioxide laser combined with photodynamic therapy
Objective:Clinical data of patients with perianal and anal condyloma acuminatum(CA)treatd by fractional carbon dioxide(CO2)laser combined with 5-aminolevulinic acid photodynamic therapy(ALA-PDT)were retrospectively analyzed to evaluate the factors that lead to relapse.Methods:Patients with perianal and anal CA who were admitted in Department of Dermatology of Affiliated Nantong Hospital 3 of Nantong University from April 2015 to December 2022 were divided into the recurrence group and the cured group.The clinical data of the two groups were analyzed.Clinical variables were analyzed based on the Cox proportional hazards regression model performed by univariate and multivariate analyses.Results:A total of 56 patients with perianal and anal CA were included in the study.Among them,8 patients experienced recurrence while the other 48 patients had no recurrence.The recurrence rate were 14.28％.Univariate and multivariate Cox regression analyses showed that,number of CO2 laser therapies(＞once time)was significantly and positively associated with recurrence in CA patients with perianal and anal involvement[HR=13.0,95％CI(2.1,79.9),P=0.006],without underlying diseases was inversely associated with recurrence in the CA patients[HR=0.1,95％CI(0,0.4),P=0.003].Conclusion:Number of CO2 laser therapies and under-lying diseases were independent influencing factors of recurrence in CA patients with perianal and anal involvement.
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