Objective:To sum up the procedural experience through analyzing the clinical data regarding transcatheter aortic valve replacement(TAVR)in our center.Methods:From October 2020 to June 2023,28 patients were treated by TAVR proce-dure in the Valvular Heart Disease Center,the Affiliated Hospital of Nantong University.The clinical data such as medical history,laboratory tests and auxiliary examinations were collected.The procedural success rate,procedural complications,in-hospital results and 6-month follow-up results were retrospectively analyzed.Results:The mean age of the 28 patients with 14 females and 14 males respectively was(75.54±6.08)years,including 22 patients with severe aortic stenosis and 6 patients with pure severe aortic regurgitation.The Society of Thoracic Surgeons average score was 4.05±3.48,and the procedural suc-cess rate was 96.43%.There were 5 patients(17.86%)implanted permanent pacemaker implantation due to degree Ⅲ atri-oventricular block.Moderate para-valvular leakage occurred in 3 patients(10.71%)during the operation,in which 1 case under-went post-balloon dilation and 2 cases underwent"valve-in-valve"technique to significantly reduce valve regurgitation.1 patient(3.57%)suffered from the valve jumping,and the second valve was implanted to fix the first one at the ascending aorta.Pericar-dial tamponade occurred in 3 patients(10.71%),in which 2 patients survived because that the hemorrhage was terminated after pericardial catheterization and protamine neutralization of heparin,while the third one left suffered from the aorticannu-lus avulsion and died after conversion to thoracotomy.During the 6 months follow-up,1 patient was re-hospitalized due to the severe anemia.The life quality of all patients was significantly improved.Conclusion:TAVR processes favourable efficacy and safety in the treatment of severe aortic valve stenosis or regurgitation.
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