The predictive value of LSM,PNI and Mayo scores in PBC-related liver cirrhosis
Objective:To investigate the predictive value of liver stiffness measurements(LSM),prognostic nutritional index(PNI),and Mayo score in primary biliary cholangitis(PBC)-related liver cirrhosis.Methods:The clinical data of 239 patients with PBC who were treated in Affiliated Nantong Third Hospital of Nantong University from January 2019 to August 2022 were collected,including 123 cases in the cholangitis group and 116 cases in the cirrhosis group.PNI and Mayo score were calculated.Multivariate Logistic regression model was used to analyze the risk factors affecting the disease progression of PBC patients,and the ROC curve was used to evaluate its predictive performance.Results:Alkaline phosphatase(ALP),total bile acid(TBA),creatinine(Cr),IgM,the positive rate of anti-gp210 antibody,LSM,and Mayo scores in the group of liver cirrhosis in PBC patients were higher than those in the cholangitis group(all P<0.05);the PNI in the liver cirrhosis group was lower than that in the cholangitis group(P<0.05).Multivariate Logistic regression analysis showed that LSM,IgM,anti-gp210,PNI,and Mayo score were independent risk factors affecting the progression of liver cirrhosis in PBC patients(P<0.05).The results of Pearson correlation analysis showed that LSM was positively correlated with Mayo score(r=0.224,P<0.001),and PNI was negatively correlated with Mayo score(r=-0.759,P<0.001).The AUC of LSM,PNI,and Mayo score were 0.776,0.839,and 0.818,respectively.And the AUC of the combined prediction model was 0.914.Conclusion:LSM,PNI,and Mayo score have good predictive value for PBC-related liver cirrhosis,and the combination of LSM,PNI,and Mayo score has higher predictive value.
NETL
NSTL
万方数据
