Two different methods of cryopreservation of breast milk effects and application on feeding of low birth weight preterm infants
Objective:To compare the effects of cold storage of fresh breast milk and frozen breast milk on feeding of prema-ture infants with low birth weight infant(LBWI).Methods:286 children with LBWI were divided into observation group(n=142)and control group(n=144)according to their families′wishes.One week after admission,the observation group was fed with chilled fresh breast milk(0-4℃,stored for less than 24 hours).The control group was fed with frozen breast milk(-20--18℃,preserved for 3-6 months).The incidence of neonatal necrotizing enterocolitis of newborn(NEC),cholestasis and bronchopulmonary dys-plasia were not significantly different between the two groups(P>0.05).Results:On the 8th day,the rate of oral feeding in the observation group has higher than that in the control group(P=0.002),and the incidence of feeding intolerance in the observa-tion group was lower than in the control group,and the differences were statistically significant(P<0.001).The establishment of intestinal flora in the observation group on day 8 was better than that in the control group,and the difference was statistically significant(P=0.041).The observation group started full oral feeding before discharge earlier than the control group,the differ-ence was statistically significant(P<0.001).The incidence of feeding intolerance and nosocomial infection before discharge in the observation group were lower than those in the control group,with statistical significance(P=0.041,P=0.046).There was no significant difference in the incidence of necrotizing enterocolitis,cholestasis and bronchopulmonary dysplasia between the two groups(P>0.05).Conclusion:Compared with frozen breast milk,cold storage of fresh breast milk can increase the rate of low birth weight premature infants fed through the mouth,make the whole through the mouth feeding started ahead of time,reduce the incidence of feeding intolerance and nosocomial infection.The results of this study to a certain extent verified the effectiveness and feasibility of fresh breast milk refrigeration in the intervention of low birth weight premature infants.
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