癌相关成纤维细胞在消化道肿瘤发生发展中的作用
The role of cancer-associated fibroblasts in the occurrence and development of gastrointestinal cancer
薛朋 1李辰龙 2蒋智豪 1潘静莹 1杨日云1
作者信息
- 1. 南通大学医学院组织学与胚胎学系,江苏 226001
- 2. 南通大学附属医院神经外科
- 折叠
摘要
作为一种高危肿瘤,消化道肿瘤在全球的前 6 大高发癌症当中共占据 5 个.癌症进展除了受癌细胞自身的影响之外,也受肿瘤微环境(tumor microenvironment,TME)的影响.在TME 中,癌相关成纤维细胞(cancer-associated fibroblasts,CAFs)是最重要的一种间质细胞成分,对肿瘤的发生有较大影响.本综述将重点阐述CAFs在消化道肿瘤中的作用,总结靶向消化道肿瘤中CAFs的相关抗肿瘤策略,以期为今后消化道肿瘤的治疗提供理论指导.
Abstract
As a high-risk tumor,digestive tract tumors occupy a total of five of the top six most prevalent cancers worldwide.Cancer progression depends not only on the cancer cell itself,but also on the physiological state and composition of the tumor microenvironment(TME)in which it is located.Cancer-associated fibroblasts(CAFs),as the main type of cell in TME,serve as an important role in cancer progression.The review aims to interpret the role of CAFs in gastrointestinal cancer and summarize the anti-tumor strategries by targeting CAFs in gastrointestinal cancer.This article aims to provide theoretical guidance for the treatment of gastrointestinal cancer in the future.
关键词
消化道肿瘤/癌相关成纤维细胞/肿瘤微环境/靶向策略Key words
gastrointestinal cancer/cancer-associated fibroblats/tumor microenvironment/targeting stragety引用本文复制引用
出版年
2024
NETL
NSTL
万方数据