Relationship between serum lipoprotein-associated phospholipase 2 and cardiac valve calcification in patients with maintenance hemodialysis
Objective:To evaluate the potential association of serum lipoprotein-associated phospholipase 2(Lp-PLA2)with the development of cardiac valve calcification(CVC)in maintenance hemodialysis(MHD)patients.Methods:A total of 100 MHD patients were divided into two groups,CVC group(44 cases)and non-CVC(56 cases)according to cardiac color Doppler ultrasound examination.The clinical characteristics and laboratory indexes were compared between the two groups.Multivariate Logistic regression analysis was used to analyze the influencing factors of CVC occurrence,and ROC curve was drawn to analyze predictive value of Lp-PLA2 on CVC.Results:The prevalence of CVC in 100 MHD patients was 44%.Mean age,dialysis duration and serum Lp-PLA2 were higher in CVC group than those in non-CVC group(P<0.05).Multivariate Logistic regression analysis showed that old age,long dialysis duration and increased serum Lp-PLA2 were independent risk factors for CVC in MHD patients.The ROC curve showed that the AUC of Lp-PLA2 predicting CVC in MHD patients was 0.840(P<0.05),which has high predictive value.Conclusion:Increased serum Lp-PLA2 was the risk factor for CVC in MHD patients,it may become an important biological marker for predicting the occurrence of CVC in MHD patients.
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