Research progress of the mechanism of baicalin causing programmed cell death in tumors
As a vital component in traditional Chinese medicine anticancer prescriptions,the efficacy of Scutellaria baicalensis(Huangqin)has been thoroughly validated through modern pharmacological research,demonstrating not only anti-tumor and sedative-anxiolytic properties but also analgesic,antibacterial,and anti-inflammatory activities.Notably,baicalin,the active constituent of Huangqin,has become the focus of research both domestically and internationally in recent years due to its potent anti-tumor activity.Through reviewing relevant literatur,it has been established that baicalin exhibits remarkable therapeutic effects against liver,breast,ovarian,gastric,and various other types of cancers.Its mechanisms encompass inhibit-ing tumor cell proliferation and inducing tumor programmed cell death(PCD),such as apoptosis,pyroptosis and ferroptosis etc.PCD,as a crucial cellular biological process,plays a pervasive role in tumor initiation and progression.Thus,investigating the mechanisms underlying baicalin-induced PCD in tumor cells holds significant importance for identifying anti-tumor therapeu-tic targets.This review aims to summarize the mechanisms of baicalin-induced PCD in tumor cells,providing a reference for further research into its anti-tumor mechanisms of action.
baicalinprogrammed cell deathanti-tumormechanism of action
万方数据
维普
