Study on the relationship between serum level of haptoglobin and gene polymorphism and Alzheimer's disease
Objective To investigate the relationship between serum levels and gene polymorphisms of haptoglobin(HP)and the occurrence of Alzheimer's disease(AD).Methods A total of 113 cases of AD patients in Department of Neurology,Xianyang Hospital,Yan'an University from January 2021 to December 2023 were selected as AD group,and 1 13 cases of volunteers for health checkup in the same period were selected as control group.HP serum levels and gene polymorphisms were compared between the two groups to analyze the effects of HP serum levels and gene polymorphisms on AD susceptibility,and the relationship between HP serum levels and gene polymorphisms and the degree of cognitive impairment in AD patients was compared in AD group.Results The serum level of HP in AD group was(2.16±0.68)µ g·mL-1,higher than that in control group(1.38±0.41)μg·mL-1(P＜0.05).The results showed that the distribution of HP genotype was representative of the population(P＞0.05).The rank sum test showed that the genotype distribution of HP1-1,HP2-1 and HP2-2 between the two groups had statistical significance(P＜0.05).x2 test showed that the frequency of allele HP1 in AD group was higher than that in control group(P＜0.05).Risk analysis showed that high serum levels of HP.HP 1-1 genotype,and carrying allele HP1 significantly increased AD susceptibility(RR=3.133,2.210,2.053;95％CI was 2.288-4.289,1.736-2.814,1.654-2.547,P＜0.05).The serum level of HP in AD group was(2.86±0.63)μg·mL-1＞(2.16±0.40)μg·mL-1＞(1.83±0.31)μg·mL-1 in patients with severe cognitive impairment＞(2.16±0.40)μg·mL-1＞(P＜0.05).The rank sum test showed that the genotype distribution of HP1-1,HP2-1 and HP2-2 of patients with different degrees of cognitive impairment in AD group had statistical significance(P＜0.05).x2 test showed that the frequency of allele HP1 in AD group was higher in patients with severe cognitive impairment than in patients with moderate cognitive impairment than in patients with mild cognitive impairment(P＜0.05).Spearman correlation analysis showed that HP serum level,genotype HP1-1 and allele HP1 were positively correlated with the degree of cognitive impairment(P＜0.05).Conclusion High levels of HP serum,HP 1-1 genotype,and carrying the allele HP1 significantly increase the risk of AD,and are closely related to the degree of cognitive impairment,providing new targets for clinical diagnosis and treatment.
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