Prediction value of somatosensory evoked potential combined with serological indexes for upper limb functioning in patients with AIS
Objective To investigate the prediction value of somatosensory evoked potential(SEP)combined with serological indexes for upper limb functioning in patients with acute ischemic stroke(AIS).Methods Patients with AIS who received drug intervention and standardized rehabilitation treatment in Liqun Hospital,Putuo District,Shanghai from July 2021 to February 2022 were selected as the study subjects.All patients received conventional medical drugs and limb rehabilitation treatment during the acute phase.SEP and serum indexes were measured at the acute stage.The recovery of upper limb function and nerve function was assessed by Fugl-Meyer evaluation(FMA)and modified Rankin score(mRS)at 48 h,3 w,and 12 w after onset.The receiver operating characteristic(ROC)curve was used to analyze SEP,S-100β,and the area under the curve(AUC)of their combination to determine the optimal diagnostic point,sensitivity,and specificity of the predictor.Results A total of 144 patients were eventually included in the study.The FMA and mRS Scores of patients at 48 h,3 w,and 12 w had more than medium negative correlation(correlation coefficients≥0.585,P＜0.001).FMA scores within 48 were strongly correlated with FMA scores at 3 w and 12 w(P＜0.001).mRS Scores at 48h were correlated with those at 3 w and12 w(P＜0.001).Multi-factor Logistics regression analysis showed that age,N20 latency,and S100[3 were independent risk factors affecting the recovery of upper limb function(P＜0.05).ROC curve results showed that the best cut-off value of N20 latency for predicting the recovery of upper limb function was 22.03ms.The optimal truncation value of S100 β was 151.82ng·L-1.When combined,the sensitivity,specificity,and AUC of upper limb function recovery were 73.57％,91.16％,and 0.917.The AUC was greater than the N20 latency and Sl00β single prediction(Z=5.427 and 5.516,P＜0.001).Conclusion There was a correlation between FMA scores and mRS scores in AIS patients.N20 latency and Sl00β in the acute phase were independent risk factors affecting the recovery of upper limb function and had predictive value for the recovery of upper limb function in patients.When the two are combined,the predictive value is higher.
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