Effects of Xingnaojing injection combined with nalmefene on neurological function,cognitive function,and serum sFas and Ang-1 levels in patients with traumatic brain injury
Objective To investigate the effects of Xingnaojing injection combined with nalmefene on neurological function,cognitive function,and serum levels of soluble factor-related apoptosis(sFas)and angiopoietin-1(Ang-1)in patients with traumatic brain injury(TBI).Methods The study population was selected from 86 patients with TBI admitted to Suzhou Hospital,Nanjing University School of Medicine from May 2020 to May 2023 who met the criteria of this study,and were divided into control group(n=43)and study group(n=43)by randomized numerical table.Reference group was treated with intravenous injection of nalmefene,while study group was treated with Xingnaojing injection based on reference group.The clinical efficacy,NIHSS score,MMSE score,serum sFas and Ang-1 levels before and after treatment,and untoward reactions were compared between the two groups.Results Compared with reference group,the total effective rate of study group increased after treatment(P＜0.05).Before the treatment,the comparison of NIHSS scores of the two groups of patients did not differ(P＞0.05),after the treatment,the NIHSS scores of the two groups were reduced,relatively speaking,the NIHSS scores of the study group were reduced more(P＜0.05).Before treatment,there was no difference in the MMSE scores of the two groups(P＞0.05),and after treatment,the MMSE scores of the two groups increased,and relatively speaking,the MMSE scores of the research group increased more(P＜0.05).Before treatment,there was no difference in the comparison of serum sFas and Ang-1 levels between the two groups(P＞0.05),while after treatment the serum sFas and Ang-1 levels of the two groups were lower than before treatment(P＜0.05),and the serum sFas and Ang-1 levels of the study group were lower than those of the control group(P＜0.05).There was no difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The combination of Xingnaojing injection and Nalmefene for TBI can improve clinical efficacy,improve neurological function and cognitive function,regulate serum sFas and Ang-1 levels,and is safe and reliable,worthy of promotion and application.
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