漆酶:一种新型靶标在农业杀菌剂开发中的潜在应用
Laccase:a novel target with potential applications in development of agricultural fungicides
路星星 1孙腾达 1徐欢 1杨新玲 1刘西莉 2张晓鸣 1凌云1
作者信息
- 1. 中国农业大学理学院应用化学系农药创新中心,北京 100193
- 2. 中国农业大学植物保护学院,北京 100193
- 折叠
摘要
目前杀菌剂分子设计多依赖于已知的靶标蛋白,但重复针对相同靶标使用杀菌剂,无疑会增大有害生物对药剂的交互抗性风险.因此,基于新的作用靶标开发新型作用机制的杀菌剂,可以有效解决病原菌对现有杀菌剂的抗性难题.漆酶是二羟基萘黑色素生物合成途径中的关键酶,目前许多研究表明其缺失可使真菌生长发育及致病侵染受到影响,可作为农用杀菌剂潜在靶标进行系统研究.本文介绍了漆酶的结构与功能,并着重介绍了近几年有漆酶抑制活性的化合物作为潜在杀菌剂的研究进展,可为更多新型漆酶抑制剂作为杀菌剂的研究提供指导.
Abstract
Consequently,identifying new green fungicides has become critical.Currently,the molecular design of fungicides depends on known targets,but the repeated use of fungicides targeting a single pathway undoubtedly increases the risk of cross-resistance in harmful organisms.Therefore,the development of fungicides with novel mechanisms of action based on new targets can effectively solve the problem of pathogenic bacteria resistance to existing fungicides.Laccase is a key enzyme in the biosynthesis pathway of dihydroxynaphthalene melanin.Its absence can affect fungal growth and development and pathogenic infestation,and may be investigated as a potential target for pesticide fungicides.This paper introduces the structure and functionality of laccase,spotlighting recent advances in the study of compounds with laccase inhibitory activity as promising agents.With the hope of providing guidance for the discovery of more novel laccase inhibitors as fungicides.
关键词
漆酶/杀菌剂靶标/漆酶抑制剂/抑菌活性/氨基硫脲衍生物Key words
laccase/fungicide target/laccase inhibitors/antifungal activity/thiosemicarbazide derivatives引用本文复制引用
基金项目
国家自然科学基金(22077137)
国家自然科学基金(21472236)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据