手性农药对映选择活性及机制研究进展
Advances on enantioselective activity and it's mechanism of chiral pesticides
朱俊琪 1李远富 1毛凯凯 1谢发扬 1谭辉华 1赵锋1
作者信息
- 1. 广西大学广西农业环境与农产品安全重点实验室,南宁 530004
- 折叠
摘要
手性农药对映体在防除各类有害生物时常表现出不同的生物活性,关注手性农药对映体的选择活性对于促进农药减施增效、发展绿色农业具有重要意义.本文综述了手性农药对映体选择活性研究现状,并将对映体的选择活性机制研究归纳为两方面:一方面大多数研究采用计算机模拟技术,分析对映体与靶标分子活性位点之间的结合能力,仅有少部分研究通过生物试验验证了分子对接的结果;另一方面研究则通过放射性同位素示踪法以及定量分析代谢物等手段,探究手性农药对映体在生物系统内吸收、运输和代谢的差异.本文旨在为识别高活性手性农药单体、开发高效低风险新型绿色农药提供参考.
Abstract
Chiral pesticide enantiomers often show different bioactivity in controlling harmful organisms.It is of great significance to pay attention to the selective activity of chiral pesticide enantiomers to promote the reduction and efficiency of pesticides and to develop green agriculture.In this paper,according to the research status of enantioselective activity of chiral pesticides,the research on enantioselective activity mechanism is summarized into two aspects:On the one hand,computer simulation technology is used to analyze the binding ability between enantiomers and active sites of target molecules,and a few of them have also carried out biological experiments;on the other hand,the study explored the differences in absorption,transportation and metabolism of chiral pesticide enantiomers in biological systems by means of radioisotope tracing and quantitative analysis of metabolites.This paper aims to provide reference for the identification of highly active activity chiral pesticide monomers and the development of new green pesticides with high efficiency and low risk.
关键词
手性农药/对映体/立体选择性/生物活性/机制Key words
chiral pesticides/enantiomers/enantioselective activity/bioactivity/mechanism引用本文复制引用
基金项目
国家自然科学基金青年科学基金(32302398)
广西科技计划青年创新人才科研专项(2022AC21245)
出版年
2024
国家科技期刊平台
NSTL
万方数据