In order to obtain acaricides of pyrazole acrylonitrile with better acaricidal activity for mitecontrol,seventeen novel ester derivatives were synthesized via four steps of Blanc chlorome-thylation reaction,dehalogenation reaction,condensation reaction and esterification reaction using ethyl 1,3-dimethyl-1H-pyrazole-5-carboxylate as the starting material.Furthermore,their acaricidal activity against Tetranychus cinnabarinus was assessed by immersion test,and the mortality rate and lethal mid-range concentration LC50 were calculated.The results show that the target compounds display excellent acaricidal activity against T.cinnabarinus,and compared with the commercial pesticide cyenopyrafen(LC50=0.61 mg/L),compounds 5q and 5k possess significantly higher acaricidal activity against T.cinnabarinuswith LC50 values of 0.17 and 0.22 mg/L,respectively.
维普
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