叶面黏附纳米载药体系CS@HMS-EB的制备及性能研究

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中文摘要：在可持续农业生产中，高效、环保的纳米载药体系是提高农药利用率和减少环境污染的有效途径。本研究以硅酸乙酯为硅源，氨水为催化剂，通过自模板合成法制备中空介孔二氧化硅(hollow mesoporous silica，HMS)，通过共溶剂法负载甲氨基阿维菌素苯甲酸盐(EB)制备纳米载药体系(HMS-EB)，进一步以壳聚糖(CS)为功能基团，经共价修饰到HMS-EB表面，制备具有良好叶面黏附的纳米载药体系CS@HMS-EB。结果表明:CS@HMS-EB呈规则球形，尺寸均匀，粒径约200 nm，载药量为45。3％。CS通过共价作用附着在HMS纳米载体表面，显著提高了 EB在玉米叶片表面的润湿、黏附和持留能力。此外，在紫外光照射下，相比EB原药，CS@HMS-EB中EB的降解率下降了 40％，且CS@HMS-EB具有良好的缓释性能。室内和田间生物活性评价结果均表明，CS@HMS-EB对草地贪夜蛾幼虫的生物活性优于市售的5％EB ME。该纳米载药体系不含有机溶剂、且具有良好的杀虫活性，在害虫防治中应用前景广阔。

外文标题：Preparation and characterization of foliar adhesion nano-drug carrier system CS@HMS-EB

外文摘要：In sustainable agricultural production,an efficient and environmentally-friendly nano-drug carrier system is a considerably efficient way to enhance the efficacy of pesticides and minimize ecological side effects.In this study,tetraethyl orthosilicate(TEOS)was used as the silicon source with ammonia as the catalyst for the synthesis of hollow mesoporous silica(HMS)by a self-template method.HMS was loaded with emamectin benzoate(EB)by co-solvent method to prepare nano-drug carrier system(HMS-EB).Chitosan(CS)was covalently modified on the surface of HMS-EB to obtain a good foliage adhesion nano-drug carrier system(CS@HMS-EB).Results showed that the prepared CS@HMS-EB had a regular spherical shape and uniform particle size,with an average particle size of about 200 nm and a drug loading rate of 45.3％.Through the covalent interaction,CS successfully adhered to the surface of HMS-EB,which significantly improved the wetting,adhesion and retention capacity of EB on the surface of maize leaves.Moreover,under UV-light irradiation,the degradation rate of EB loaded in the CS@HMS-EB decreased by 40％compared with EB alone.Meanwhile,CS@HMS-EB had a good sustained release property.Importantly,Both indoor and field bioactivity evaluation assays showed that compared with commercial 5％emamectin benzoate microemulsion(EB ME),CS@HMS-EB exhibited higher insecticidal activity against Spodoptera furgiperda larvae.This nano-drug carrier system does not contain organic solvents and has good insecticidal activity,which is expecting to play a broad application prospect in pest control.

外文关键词：

hollow mesoporous silicaemamectin benzoatechitosanfoliar adhesionSpodoptera furgiperda

作者：

陈秀琴、邱良妙、刘其全、何玉仙

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作者单位：

福建省农业科学院植物保护研究所,福建省作物有害生物监测与治理重点实验室,福州 350013

关键词：

中空介孔二氧化硅甲氨基阿维菌素苯甲酸盐壳聚糖叶面黏附草地贪夜蛾

基金：

福建省自然科学基金项目福建省农业高质量发展超越"5511"协同创新工程项目福建省农业高质量发展超越"5511"协同创新工程项目福建省农业科学院自由探索科技创新项目福建省科技计划公益类专项中央引导地方科技发展专项

项目编号：

2021J05088XTCXGC2021011XTCXGC2021017ZYTS2022112021R10240082023L3059

出版年：

2024

DOI：

10.16801/j.issn.1008-7303.2024.0083

农药学学报

中国农业大学

农药学学报

CSTPCD北大核心

影响因子：0.879

ISSN：1008-7303

年,卷(期)：2024.26(5)