Synthesis and insecticidal/acaricidal activities of 15-chloro-18-alkyl(benzyl)oxyiminomethyne derivatives of sophoridine
Sophoridine is a quinolizidine alkaloid isolated from Sophora flavescens and Sophora alopecuroides.Its medical activities include anticancer,anti-inflammation,etc.,but little pesticide research.To improve the agricultural value of sophoridine,a series of 15-chloro-18-alkyl(benzyl)oxyi-minomethyne derivatives were designed and synthesized through structural modification at C-14 and C-15 positions.Compound 4i(R=4-NO2Bn)showed good acaricidal activity against female adults of Tetranychus cinnabarinus.Its 72 h LC50 value was 0.408 mg/mL,and its acaricidal activity was 8.5 times that of sophoridine(LC50=3.48 7 mg/mL).At the concentration of 1 mg/mL,compound 4f(R=4-BrBn)had the best insecticidal activity against Mythimna separata,with a 35 d corrected mortality rate of 62.3％.These results will provide a basis for using sophoridine derivatives as acaricides and insecticides.
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维普
