Determination of 11 Common Drugs in Sewage by Automatic On-line Solid Phase Extraction Liquid Chromatography-mass Spectrometry
Sewage epidemiology has become an important means to monitor drug abuse in an area.Solid-phase extraction is usually used for enrichment and purification of drug in sew-age,and liquid chromatography tandem mass spectrometry is used for qualitative and quanti-tative analysis.Most of the off-line solid-phase extraction methods are time-consuming and laborious.The purpose of this paper is to establish a fully automatic on-line solid-phase ex-traction method to carry out the full-automatic monitoring of 11 common drugs in sewage.In the whole method,the internal standard is automatically added to the sample,mixed,in-jected in large volume,and the on-line solid phase extraction is automatically performed to enrich and purify the sample.The results of method validation showed that the method was stable and reliable,and the recovery ranged from 87.7%to 113.8%.The relative standard deviation RSD of the concentrations of all compounds was 1.79%—7.39%.The method has high sensitivity,good accuracy and repeatability,and can fully meet the needs of sewage drug monitoring.At the same time,the method is applied to the determination of actual sewage samples with good results.
sewageautomationon line solid phase extractiondrugs
万方数据
维普
