Nano-micelles from a New Triblock Polypeptoid Based on N-Hexylglycine
A poly(N-ethylene glycol)-b-poly(hexylglycine)-b-poly(N-allylglycine)triblock copolymer conjugated with mercaptoethylamine(PEG-b-PNHG-b-P(NAG-g-NH2))was synthesized by ring-opening polymerization(ROP).The polymer can spontaneously assem-ble into highly uniform and ordered wormlike micelles in water driven by crystallization and amphiphilicity,with a length of 120 nm.As the solution was adjusted to an acidic condition,spherical micelles with a diameter of 20 nm were formed.This crystallization-driven self-assembly behavior provides a simple method for preparing supramolecular nanostructures.Moreover,due to the excellent biocompatibility of polypeptoid,the micelles show great po-tential in nanomaterials and biomedical applications.
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