Silver Catalyzed Site-Selective C(sp3)—H Bond Amination of Benzyl Over Propinyl C(sp3)—H Bond
In recent years,construction of C—N bonds through nitrogen source provided by nitrene has become a novel and important synthesis strategy in organic reactions,further-more,these methods have been widely used in pharmaceutical chemistry and total synthesis of natural products.In this paper,the AgClO4/tris(2-pyridylmethyl)amine catalyzed intra-molecular site-selective amination of benzyl C(sp3)—H bond and propinyl C(sp3)—H bond to give the cyclic sulfamates in 89%yields and 9.2∶1 site-selectivity.This reaction has the advantages of mild conditions,good functional group tolerance,high atom economy and step economy,which provides a strategy for the construction of C—N bonds.
silver-catalyzed nitrenesite-selective aminationcyclic sulfamate derivativesbenzyl C(sp3)—H bond
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