苦黄颗粒治疗酒精性肝病并皮肤瘙痒的临床疗效观察
Clinical Efficacy of Kuhuang granules on Treatment of Alcoholic Liver Disease With Skin Pruritus
楚洪亮 1李梅 2郝长河3
作者信息
- 1. 青岛市第六人民医院老年病科,山东青岛 266011
- 2. 青岛市黄岛区区立医院中医科,山东青岛 266400
- 3. 青岛市黄岛区中医医院肝胆科,山东青岛 266000
- 折叠
摘要
目的 观察苦黄颗粒对酒精性肝病合并皮肤瘙痒症患者临床症状改善及肝功能指标的影响.方法 选择2022年5月～2022年11月青岛市黄岛区中医医院及青岛市第六人民医院门诊及病房就诊的酒精性肝病合并皮肤瘙痒患者共168例,随机分为2组(1∶1),每组84例.对照组采用还原型谷胱甘肽静脉滴注治疗,观察组在对照组基础上联用苦黄颗粒口服治疗,疗程4周.统计2组患者临床疗效、治疗后黄疸消退时间及皮肤瘙痒消退时间,对治疗前后血清天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、总胆红素(TBIL)等指标进行水平检测.结果 观察组有效率明显高于对照组(97.62％vs 88.10％,P＜0.05);治疗后,观察组黄疸消退时间为(15.31±5.51)天,明显短于对照组(21.13±6.08)天,观察组皮肤瘙痒消退时间为(12.88±5.14)天,明显短于对照组(20.28±6.24)天(均P＜0.05);治疗前,2组患者AST、ALT、TBIL水平没有显著性差异(均P＞0.05);治疗后,2组AST、ALT、TBIL水平明显降低,且观察组优于对照组(均P＜0.05).结论 苦黄颗粒治疗酒精性肝病合并皮肤瘙痒症疗效明显,可改善患者异常肝功能指标,改善黄疸及皮肤瘙痒症,缩短病程.
Abstract
Objective To observe the effect of Kuhuang Granules on the improvement of clinical symptoms and liver function indexes in patients with alcoholic liver disease complicated with pru-ritus.Methods A total of 168 patients with alcoholic liver disease combined with skin pruritus were selected from the outpatient department and ward of Huangdao District Hospital of Tradi-tional Chinese Medicine and the Sixth People's Hospital of Qingdao from May 2022 to November 2022,and were randomly divided into 2 groups(1∶1),with 84 patients in each group.The con-trol group received intravenous infusion of reduced glutathione for treatment,while the observa-tion group received oral treatment with Kuhuang granules in combination with the control group for 4 weeks.The clinical effects of the two groups were analyzed,and the time of jaundice resolu-tion and skin pruritus resolution after treatment were compared.Serum levels of aspartate amin-otransferase(AST),alanine aminotransferase(ALT)and total bilirubin(TBIL)were measured before and after treatment.Results The effective rate of the observation group was significantly higher than that of the control group(97.62％vs 88.10％,P＜0.05);After treatment,the jaundice resolution time in the observation group was(15.31±5.51)days,significantly shorter than that in the control group(21.13±6.08)days,and the skin pruritus resolution time in the observation group was(12.88±5.14)days,significantly shorter than that in the control group(20.28±6.24)days(all P＜0.05);Before treatment,there was no significant difference in the levels of AST,ALT,and TBIL between the two groups of patients(all P＞0.05);After treat-ment,the levels of AST,ALT,and TBIL in both groups were significantly reduced,and the observa-tion group was better than the control group(all P＜0.05).Conclusion Kuhuang granules have a sig-nificant therapeutic effect on alcoholic liver disease combined with skin pruritus,which can improve ab-normal liver function index,improve jaundice and skin pruritus,shorten the course of disease.
关键词
苦黄颗粒/酒精性肝病/肝功能/临床特征/皮肤瘙痒Key words
Kuhuang granules/Alcoholic liver disease/Liver function/Clinical features/Skin pruritus引用本文复制引用
出版年
2024
NETL
NSTL
万方数据