Objective To analyze recurrence data from 912 breast cancer patients at our center and identify Influencing factors affecting disease-free survival in breast cancer.Methods The study included 912 breast cancer patients treated at the First Affiliated Hospital of Dalian Medical Uni-versity from January 2010 to December 2016.Patients'ages ranged from 24 to 87 years,with an average age of 54.81±11.63 years.There were 202 patients with T2DM and 710 without T2DM.By the end of follow-up,88 patients had experienced recurrence,while 824 had not.Uni-variate and multivariate Cox regression analyses were used to identify risk factors affecting disease-free survival in breast cancer.Kaplan-Meier survival curves were plotted,and Wilcoxon and Logrank tests were used to evaluate differences between survival curves.Results Uni-variate Cox regres-sion analysis indicated that age,T2DM,breast treatment,armpit treatment,T stage,N stage,molecular type,ER1,ER2,and PR were risk factors for breast cancer recurrence survival time(p＜0.05).Higher age,T2DM,tumor size ≥ 2 cm,axillary lymph node metastasis ≥4 nodes,and ER＞10％were independent risk factors affecting post-operative recurrence time in breast cancer(p＜0.05).Survival curves plotted for factors such as T2DM showed significant differ-ences between groups(p＜0.05).Conclusion T2DM is an important factor affecting disease-free survival in breast cancer.Early detection and treatment are crucial for improving prognosis.
关键词
乳腺癌/2型糖尿病/无复发生存期/临床病理资料
Key words
Breast Cancer/T2DM/Disease-Free Survival/Clinic-pathological Data
维普
万方数据