Objective To investigate the relationship between the polymorphism at rs2074192 of the angiotensin-converting enzyme 2 gene(ACE2)and susceptibility to nonalcoholic fatty liver disease(NAFLD)in a population of Qingdao Province,China.Methods A total of 208 patients with NAFLD and 105 healthy subjects were included.DNA was extracted from their blood sam-ples to determine the genotype of rs2074192 of the ACE2 gene by using polymerase chain reaction.The frequency distributions of ACE2 rs2074192 genotypes and alleles were compared between the NAFLD group and control group.The clinical data and labora-tory results of patients carrying different genotypes were compared.Results There were no significant differences in the distri-butions of ACE2 rs2074192 genotypes and alleles between the NAFLD group and the control group(P＞0.05).Among female pa-tients,the body mass index was significantly higher in T allele carriers than in those not carrying the T allele at ACE2 rs2074192(t=-2.613,P＜0.05).Among male patients,serum glucose level was significantly lower in T allele carriers than in those not har-boring the T allele(t=-3.195,P＜0.05).Conclusion There was no significant association of ACE2 rs2074192 polymorphism with NAFLD susceptibility in the Qingdao population.
关键词
非酒精性脂肪性肝病/多态性,限制性片段长度/血管紧张素转换酶2/疾病遗传易感性
Key words
non-alcoholic fatty liver disease/polymorphism,restriction fragment length/angiotensin-converting enzyme 2/genetic predisposition to disease
维普
万方数据