Objective To investigate the association of fasting blood glucose(FBG)with cerebrospinal fluid biomarkers for Alzheimer's disease(AD)in the non-diabetic population without dementia.Methods A total of 1 158 non-diabetic participants without dementia were selected as research subjects from AD Neuroimaging Initiative database.The multiple linear regression mo-del and the linear mixed-effects model were used to investigate the cross-sectional and longitudinal relationships between FBG level and the cerebrospinal fluid biomarkers for AD including β-amyloid(Aβ),total tau(t-tau),and phosphorylated tau(p-tau).Results The cross-sectional analysis showed that FBG was positively associated with t-tau(β=0.124,P=0.001)and p-tau(β=0.113,P=0.003)and was not associated with Aβ42(β=0.067,P=0.144);FBG level was associated with the longitudinal accu-mulation of t-tau(β＜0.001,P=0.025)and p-tau(β＜0.001,P=0.014)and was not associated with the longitudinal changes of Ap42(β=-0.004,P=0.716).The subgroup analysis showed that in female participants,FBG level was positively associated with t-tau(β=0.119,P=0.002)and p-tau(β=0.129,P=0.024),while in male participants,FBG was only positively associated with t-tau(β=0.101,P=0.047).FBG was positively associated with t-tau(β=0.118,P=0.004)and p-tau(β=0.110,P=0.007)only in participants aged 65 years and above.In APOE e4 gene carriers,the increase in FBG level was associated with the increases in t-tau(β=0.160,P=0.012)and p-tau(β=0.154,P=0.017).Conclusion FBG level is positively associated with t-tau and p-tau in cerebrospinal fluid,and lowering FBG level may have a protective effect against pathological changes in AD.
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