Objective To preliminarily evaluatethe therapeutic effects of irreversible electroporation for primary liver cancer.Methods From January 2019 to October 2021,we prospectivelyenrolled 102 patients with primary liver cancer who were trea-ted at Hebei PetroChina Central Hospital,and assigned them using a random number tableto receive either irreversible electropora-tion(observation group)or radiofrequency ablation(control group),with 51 patients in each group.The two groups were com-pared in terms of clinical response,postoperative complications,survival and recurrence rates at 6 and 12 months,and the clea-rancerate of alpha fetoprotein(AFP),as well as biochemical indicators including total bilirubin(TBil),albumin(Alb),alanine ami-notransferase(ALT),carbohydrate antigen 125(CA125),carcinoembryonic antigen(CEA),and AFP levels.Results Com-pared with the control group,the observation group showed significantly higher overall clinical response rate,6-and 12-month sur-vival rates,and AFP clearance rate(x2=7.933,8.254;Log-rank x2=8.254,8.541;all P＜0.05)and significantly lower incidence rate of postoperative complications and recurrence rates at 6 and 12 months(x2=4.317;Log-rank x2=6.331,7.256;all P＜0.05).ALT,Alb,TBil,AFP,CEA,and CA125 levels in the observation group were significantly lower than those in the control group(t=8.660-40.741,all P＜0.05).Conclusion Irreversible electroporation has significant therapeutic effectsforpatients with pri-mary liver cancer,and can effectively reduce serum ALT,Alb,and TBil levels,with less detrimental impact on liver function.
关键词
肝肿瘤/电穿孔/射频消融术/肝功能试验/生物标记,肿瘤/治疗结果
Key words
liver neoplasms/electroporation/radiofrequency ablation/liver function tests/biomarkers,tumor/treatment outcome
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