血清硒蛋白P与类风湿关节炎的相关性
Association between serum selenoprotein P and rheumatoid arthritis
周雪梅 1吴颖慧 1温大蔚 1辛苗苗 1梁宏达1
作者信息
- 1. 青岛大学附属医院风湿免疫科,山东 青岛 266000
- 折叠
摘要
目的 探讨血清硒蛋白P与类风湿关节炎(RA)的相关性.方法 选取RA病人96例为研究对象(RA组),根据疾病活动度评分分为稳定期49例,活动期47例;选取同期健康查体者50例为对照组.采用ELISA法检测两组血清硒蛋白P浓度.结果 RA组与对照组血清硒蛋白P浓度差异有统计学意义(t=-7.169,P＜0.001);RA稳定组与活动组血清硒蛋白P浓度差异有统计学意义(t=-4.964,P＜0.001),C反应蛋白(CRP)、红细胞沉降率(ESR)差异也均有统计学意义(Z=-4.796、-4.194,P＜0.05).二分类Logistic回归分析显示,高硒蛋白P、高CRP的RA病人疾病活动度增高的风险增加(OR=1.286～1.368,P＜0.05).结论 血清硒蛋白P是RA病人疾病活动的独立危险因素.
Abstract
Objective To investigate the association between serum selenoprotein P and rheumatoid arthritis(RA).Methods A total of 96 patients with RA were enrolled as subjects(RA group),and according to the disease activity score,they were divided into stable RA group with 49 patients and active RA group with 47 patients;50 individuals who underwent physical examination during the same period of time were enrolled as control group.ELISA was used to measure the concentration of serum selenoprotein P.Results There was a significant difference in the concentration of serum selenoprotein P between the RA group and the control group(t=-7.169,P＜0.001),and there were significant differences between the stable RA group and the active RA group in the concentration of serum selenoprotein P(t=-4.964,P＜0.001),C-reactive protein(CRP)(t=-4.796,P＜0.05),and erythrocyte sedimentation rate(t=-4.194,P＜0.05).The binary Logistic regression analysis showed that RA patients with high levels of selenoprotein P and CRP had an increased risk of the increase indisease activity(OR=1.286-1.368,P＜0.05).Conclusion Serum selenoprotein P is an independent risk factor for disease activity in patients with RA.
关键词
关节炎,类风湿/硒蛋白P/免疫/预后Key words
arthritis,rheumatoid/selenoprotein P/immunity/prognosis引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据