Sirt6在肾脏病中的研究进展
Research advances in Sirt6 in kidney disease
魏玉娇 1陈超 1李明慧 1徐晓燕 1邱蕊 1马瑞霞2
作者信息
- 1. 青岛大学附属医院急诊内科,山东青岛 266100
- 2. 青岛大学附属医院肾病科,山东青岛 266100
- 折叠
摘要
Sirtuins蛋白家族是进化保守的烟酰胺腺嘌呤二核苷酸依赖性组蛋白去乙酰化酶家族.Sirt6作为Sirtuins家族的重要一员,广泛分布在肾小球足细胞及肾小管细胞中,通过维持足细胞及线粒体稳态、抑制炎症、纤维化等多种途径发挥肾脏保护作用.本文主要概述Sirt6的结构及其在糖尿病肾脏疾病、急性肾损伤、高血压肾病等肾脏病中的作用及机制,为肾脏疾病的诊治提供新的靶点.
Abstract
The Sirtuins protein family is an evolutionarily conserved NAD+-dependent histone deacetylase family.Sirt6,as an important member of the Sirtuins family,is widely distributed in glomerular podocytes and renal tubular cells and exerts a renal protective effect through various pathways such as maintaining the homeostasis of podocytes and mitochondria and inhibiting in-flammation and fibrosis.This article reviews the structure of sirt6 and its role and mechanism in various renal diseases including di-abetic kidney disease,acute kidney injury,and hypertensive nephropathy,so as to provide a new target for the diagnosis and treat-ment of renal diseases.
关键词
抗衰老酶/Sirt6/肾疾病/综述Key words
sirtuins/Sirt6/kidney diseases/review引用本文复制引用
基金项目
青岛市公共领域科技支撑计划(2012-1-3-2-2-nsh)
青岛大学医学部"临床+X"工程科研项目(RZ-1900003244)
出版年
2024
国家科技期刊平台
NSTL
万方数据