Objective To investigate the role of Exendin-4,a glucagon-like peptide-1(GLP-1)receptor agonist,and endo-genous GLP-1 in regulating the spontaneous discharge activity of globus pallidus neurons inrats.Methods In vivo extracellular electrophysiological recordings were performed to observe the effect of micro-pressure injection of 10 μmol/L Exendin-4 or 10 μmol/L Exendin-9-39,a GLP-1 receptor antagonist,on the spontaneous discharge activity of globus pallidus neurons in normal rats.Results As for the 16 globus pallidusneurons of normal rats recorded,micro-pressure injection of Exendin-4 significantly increased the spontaneous discharge frequency of 11 neurons(t=-4.729,P=0.001),showing a significant difference compared with the normal saline control group(Z=2.776,P＜0.01),and it significantly changed the discharge pattern(t=-3.136,P＜0.05),with a reduction in the regularity of discharge.As for the 9 globus pallidusneurons of normal rats recorded,micro-pressure injection of Exendin-9-39 significantly reduced the spontaneous discharge frequency of 6 neurons(t=6.374,P=0.001),showing a significant difference compared with the normal saline control group(Z=-2.739,P＜0.01),but it didnot change the discharge pattern.Conclusion Exendin-4 increases the spontaneous discharge frequency of globus pallidus neurons and changes their discharge pattern,and endogenous GLP-1 is involved in the modulation of the spontaneous discharge activity of globus pallidus neurons.
维普
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