Objective To investigate the association of the preoperative serum tumor marker CA125 and ascites with the peritoneal metastasis of pancreatic cancer,and to provide a basis for the early diagnosis of peritoneal metastasis of pancreatic can-cer.Methods A total of 24 patients who underwent surgical operation in our hospital due to peritoneal metastasis of pancreatic cancer from January 2018 to December 2021 were enrolled,as well as 89 pancreatic cancer patients without peritoneal metastasis.The indicators such as CA125 and ascites status were collected to analyze their association with peritoneal metastasis.Results There were significant differences in the degree of tumor differentiation,CA199,CA125,and ascites status between the pancreatic cancer patients with peritoneal metastasis and those without peritoneal metastasis(x2=6.43-9.54,P＜0.05).CA125(OR=1.189,95％CI=1.040-1.358)and ascites(OR=1.037,95％CI=0.806-1.225)were independent risk factors for peritoneal me-tastasis of pancreatic cancer.The combination of CA125 and ascites had a significantly larger area under the ROC curve than CA125 or ascites alone(0.953 vs 0.941/0.859,Z=3.950,4.158,P＜0.001).Conclusion CA125 and ascites are independent risk factors for peritoneal metastasis of pancreatic cancer,and combined measurement of CA125 and ascites can improve the diagnostic accuracy of peritoneal metastasis of pancreatic cancer.
维普
万方数据