Expression of long non-coding RNA transcription factor 7-like 2 in epithelial growth factor receptor-mutant non-small cell lung cancer and its association with clinicopathological features and prognosis
Expression of long non-coding RNA transcription factor 7-like 2 in epithelial growth factor receptor-mutant non-small cell lung cancer and its association with clinicopathological features and prognosis
Objective To investigate the expression of long non-coding RNA(LncRNA)transcription factor 7-like 2(TCF7L2)in epidermal growth factor receptor(EGFR)-mutant non-small cell lung cancer(NSCLC),as well as its association with the clinicopathological features and prognosis of patients.Methods A total of 104 patients with EGFR-mutant NSCLC who were treated in the First Affiliated Hospital of Hebei North University from March 2019 to June 2021 were enrolled as subjects,and RT-PCR was performed for their cancer tissue and paracancerous tissue to measure the expression of LncRNA TCF7L2.The expression level of TCF7L2 was compared between different tissue samples,and its association with clinicopathological features and prognosis was analyzed.Results RT-PCR showed that the expression level of LncRNA TCF7L2 in cancer tissue was significant-ly higher than that in paracancerous tissue(t=12.410,P＜0.05).Compared with the patients with a low expression level of LncRNA TCF7L2,the patients with a high expression level of LncRNA TCF7L2 had a significantly higher incidence rate of lymph node metastases and a significantly larger tumor diameter(x2=4.579,7.762;P＜0.05),as well as a lower survival rate at 6,9,and 12 months(P＞0.05).Conclusion For patients with EGFR-mutant NSCLC,the expression level of LncRNA TCF7L2 in cancer tissue is higher than that in paracancerous tissue,and the patients with a high expression level of TCF7L2 tend to have a higher risk of lymph node metastasis,a larger tumor diameter,and a lower survival rate.
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