Objective To investigate the clinicopathological features and prognostic factors of very young breast cancer(VYBC)patients aged under 25 years.Methods A total of 399 female breast cancer patients aged under 25 years were obtained from the Surveillance,Epidemiology,and End Results database.The chi-square test and the Cox proportional-hazards regression model were used to analyze the clinicopathological features and prognostic factors of the patients included in this study.Results The 2-,3-,5-,and 10-year overall survival rates of the 399 patients were 94.6％,91.3％,86.6％,and 78.7％,respectively.There were significant differences in estrogen receptor(ER)status and the composition ratio of molecular subtypes between the ≤20 years group and the 21-25 years group(x2=5.289,P＜0.05;the Fisher's exacttest:P=0.031).There were significant diffe-rences in histological grading(x2=55.692,P＜0.001),clinicopathological staging(P=0.024),and T stage(P=0.001)between the patients with different molecular subtypes.The multivariate analysis showed that ER status,T stage,N stage,and Mstage were independent prognostic factors for the overall survival(OS)of VYBC patients(HR=0.385-6.532,95.0％CI=(0.150-2.644)to(0.985-16.964),all P＜0.05),while surgical methods and other variables were not independent prognostic factors for OS(all P＞0.05).Conclusion ER status,T stage,N stage,and M stage can help to predict the survival and prognosis of VYBC patients in clinical practice,and the selection of surgical procedure is not associated with the OS of VYBC patients.
关键词
乳房肿瘤/青年人/病理学,临床/预后/比例危险度模型/数据库,事实型
Key words
breast neoplasms/young adult/pathology,clinical/prognosis/proportional hazards models/databases,factual
维普
万方数据