Objective To investigate the correlation of brain wave and electroencephalography(EEG)band power with event-related potential P300 in patients with primary insomnia,and to provide an objective basis for evaluating the impact of prima-ry insomnia on brain function and cognitive function.Methods A total of 31 patients with primary insomnia were enrolled as subjects(insomnia group),and 31 healthy adults were enrolled as control group.Routine EEG monitoring and event-related poten-tial P300(P3a and P3b)examination were performed for both groups to investigate the proportion of brain waves,EEG band po-wer,and the latency and amplitude of P3a and P3b,and a correlation analysis was performed.Results There were significant differences between the insomnia group and the control group in the latency and amplitude of P3a and P3b,the proportion of EEG a wave and EEG β wave,FTT-β frequency power,and FTT-total frequency power(Z=-6.84 to-1.99,P＜0.05).The propor-tion of EEG β wave and FTT-β frequency power were positively correlated with P3b latency(r=0.483,0.517;P＜0.05)and were negatively correlated with P3b amplitude(r=-0.540,-0.691;P＜0.01).Conclusion There are increases in EEG β waves and FTT-β frequency power in patients with insomnia,along with the changes in event-related potential P300,which can provide an ob-jective basis for evaluating the brain function alterations and cognitive impairment caused by insomnia.
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