Objective To explore the risk factors for aspirin resistance(AR)in elderly females with large-artery atheroscle-rotic(LAA)cerebral infarction,and to provide a basis for individualized treatment.Methods A total of 308 elderly female pa-tients with LAA cerebral infarction who were treated in The Affiliated Hospital of Qingdao University from January 2015 to Sep-tember 2020 were enrolled in the study.All the patients included were given enteric-coated aspirin tablets 100 mg/d and were tested for the inhibition rate of arachidonic acid(AA)-induced platelet aggregation(AA inhibition rate)using thromboelastography(TEG)after 7 days;the patients were then divided into AR group and aspirin-sensitive(AS)group according to the AA inhibition rate.Univariate analysis and multivariate Logistic regression analysis were used to identify the risk factors for AR in patients with LAA cerebral infarction.Results Among the 308 patients with LAA cerebral infarction,74 cases(24.0％)had AR and 234 had AS.The univariate analysis showed that the proportion of patients with diabetes history and fibrinogen and D-dimer levels were sig-nificantly higher in the AR group than in the AS group(x2=4.147,t=2.529,U=5 470.500,P＜0.05).The multivariate Logistic regression analysis showed that diabetes history and high D-dimer level were independent risk factors for AR.Conclusion Dia-betes history and high D-dimer level constitute independent risk factors for AR,which help with the early identification of high-risk population of AR.
维普
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