Spermatogonial stem cells(SSC)arethe most primitive germ cells in the testis and develop into mature sperms through self-renewal and continuous differentiation.SSC play an important role in maintaining efficient spermatogenesis,and the complex molecular and cellular interactions between SSC and microenvironment(also called niche)form the basis of spermatogene-sis.Previous studies believed that the niche was mainly composed of Sertoli cells,but recent studies have shown that various types of cells and molecular signaling pathways in the testis are involved in the regulation of the self-renewal and differentiation of SSC.This article reviews the research advances in the microenvironment for spermatogenesis in the testis in regulating the self-renewal and differentiation of SSC.
维普
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